“Derek Shepherd is the sweet sensitive type. Whether or not he makes bad decisions, there’s always nobleness about him that’s very attractive. Patrick is more complex and interesting than Derek. He has those smiling Irish eyes and a bubbly, fun personality. Regardless of how everyone praises him or the attention he gets, he’s in on the joke and he knows the reality of the situation- that fame and looks are fleeting… He appreciates what he has- that Hollywood is a means to an end. It’s a way to get back to Maine with his family, which is ultimately where he wants to be. He knows what’s real in life, and that’s his family. He lives and breathes for those kids. He’s so excited about having twin boys. And Talula is daddy’s little girl. She can do no wrong in his eyes– until she’s 16 and starts dating!”

-on Grey’s Anatomy costar Patrick “McDreamy” Dempsey

“It’s gross. We use real brains. I think they’re lamb or cow or something. Intestines smell. Brains don’t really smell, but what’s amazing about the brain is that it’s almost like scrambled eggs or soft tofu, almost like a gel. The brain controls so much of what we do, but you could put your finger right through it.”

-on filming Grey’s Anatomy

“The trap is when you start to pay attention to that stuff and care, because in six months, they’re going to be looking at someone else. You know how fickle everyone is. They love it, then they hate it, then they love it. So I’m going to enjoy it because it could be over at any minute.”

- On fame

“It’s pretty remarkable how many people the show touches… I think we are very lucky in that way so, I love when the fans come up to us because they usually have really interesting stories. We are very grateful to the fans, we would have no show without them, you know? You could have the best writing in the world, and you could have the best acting in the world, but if the fans don’t tune in every week, there’s no show. So, I think we have them to be the most thankful for.”

“The chemistry between the cast is very important. We’re a family and have respect for each other. And we have fun, which comes across.”

- On the hit show Grey’s Anatomy

“Today’s the day, people. Today’s the day when dark and twisty Meredith disappears forever, and bright and shiny Meredith takes her place. You probably won’t want to be my friend anymore, because the sheer intensity of my happiness will make your teeth hurt, but I’m ok with that, because… Life. Is. Good.

“At some point, you have to make a decision. Boundaries don’t keep other people out. They fence you in. Life is messy. That’s how we’re made. So, you can waste your lives drawing lines. Or you can live your life crossing them. But there are some lines… that are way too dangerous to cross.”

“Maybe we like the pain. Maybe we’re wired that way. Because without it, I don’t know; maybe we just wouldn’t feel real. What’s that saying? Why do I keep hitting myself with a hammer? Because it feels so good when I stop.”

“A couple of hundred years ago, Benjamin Franklin shared with the world the secret of his success. Never leave that till tomorrow, he said, which you can do today. This is the man who discovered electricity. You think more people would listen to what he had to say. I don’t know why we put things off, but if I had to guess, I’d have to say it has a lot to do with fear. Fear of failure, fear of rejection, sometimes the fear is just of making a decision, because what if you’re wrong? What if you’re making a mistake you can’t undo? The early bird catches the worm. A stitch in time saves nine. He who hesitates is lost. We can’t pretend we hadn’t been told. We’ve all heard the proverbs, heard the philosophers, heard our grandparents warning us about wasted time, heard the damn poets urging us to seize the day. Still sometimes we have to see for ourselves. We have to make our own mistakes. We have to learn our own lessons. We have to sweep today’s possibility under tomorrow’s rug until we can’t anymore. Until we finally understand for ourselves what Benjamin Franklin really meant. That knowing is better than wondering, that waking is better than sleeping, and even the biggest failure, even the worst, beat the hell out of never trying.”

“I can’t think of a single reason why I should be a surgeon, but I can think of a thousand reasons why I should quit. They make it hard on purpose… there are lives in our hands. There comes a moment when it’s more than just a game, and you either take that step forward or turn around and walk away. I could quit but here’s the thing, I love the playing field.”

“We’re adults. When did that happen? And how do we make it stop?”

“You know how when you were a little kid and you believed in fairy tales, that fantasy of what your life would be, white dress, prince charming who would carry you away to a castle on a hill. You would lie in bed at night and close your eyes and you had complete and utter faith. Santa Claus, the Tooth Fairy, Prince Charming, they were so close you could taste them, but eventually you grow up, one day you open your eyes and the fairy tale disappears. Most people turn to the things and people they can trust. But the thing is its hard to let go of that fairy tale entirely cause almost everyone has that smallest bit of hope, of faith, that one day they will open their eyes and it will come true.”

“Communication. It’s the first thing we really learn in life. Funny thing is, once we grow up, learn our words and really start talking, the harder it becomes to know what to say. Or how to ask for what we really need.”

“And if we’re lucky, we realize, in the face of everything, in the face of life, the true dream is being able to dream at all.”

“At the end of the day faith is a funny thing. It turns up when you don’t really expect it. It’s like one day you realize that the fairy tale may be slightly different than you dreamed. The castle, well, it may not be a castle. And it’s not so important happy ever after, just that its happy right now. See once in a while, once in a blue moon, people will surprise you , and once in a while people may even take your breath away.”

“Okay, here it is, your choice… it’s simple, her or me, and I’m sure she is really great. But Derek, I love you, in a really, really big ‘pretend to like your taste in music, let you eat the last piece of cheesecake, hold a radio over my head outside your window’, unfortunate way that makes me hate you, love you. So pick me, choose me, love me.”

“I need to put her to rest. I need to not become her. I need to not die emotionally crippled and alone. I need to not attend the wedding of Derek Shepherd and Sydney Heron. I NEED TO PUT MY MOTHER TO REST.”

“You know, just because people do horrible things… it doesn’t always mean they’re horrible people.”

“Maybe we’re not supposed to be happy. Maybe gratitude has nothing to do with joy. Maybe being grateful means recognizing what you have for what it is. Appreciating small victories. Admiring the struggle it takes simply to be human. Maybe we’re thankful for the familiar things we know. And maybe we’re thankful for the things we’ll never know. At the end of the day, the fact that we have the courage to still be standing is reason enough to celebrate.”

“Sometimes reality has a way of sneaking up and biting us in the ass. And when the dam bursts, all you can do is swim. The world of pretend is a cage, not a cocoon. We can only lie to ourselves for so long. We are tired, we are scared, denying it doesn’t change the truth. Sooner or later we have to put aside our denial and face the world. Head on, guns blazing. De Nile. It’s not just a river in Egypt, it’s a freakin’ ocean. So how do you keep from drowning in it?”

“Pain, you just have to ride it out, hope it goes away on its own, hope the wound that caused it heals. There are no solutions, no easy answers, you just breath deep and wait for it to subside. Most of the time pain can be managed but sometimes the pain gets you where you least expect it. Hits way below the belt and doesn’t let up. Pain, you just have to fight through, because the truth is you can’t outrun it and life always makes more.”

“I’ve heard that it’s possible to grow up – I’ve just never met anyone who’s actually done it. Without parents to defy, we break the rules we make for ourselves. We throw tantrums when things don’t go our way, we whisper secrets with our best friends in the dark, we look for comfort where we can find it, and we hope – against all logic, against all experience. Like children, we never give up hope…”

“I wish there were a rulebook for intimacy. Some kind of guide to tell you when you’ve crossed the line. It would be nice if you could see it coming, and I don’t know how you fit it on a map. You take it where you can get it, and keep it as long as you can. And as for rules, maybe there are none. Maybe the rules of intimacy are something you have to define for yourself.”